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HerediT™ Cystic Fibrosis Carrier Screen
Because parenting starts before birth.

Information that can help you plan.

When you’re planning a family, it’s natural to worry about the health of your baby. Many parents choose to have genetic testing to learn more about conditions that could affect their family.

Cystic fibrosis (CF) is one of the most common inherited health problems. Most people who carry mutations (changes) in the gene for CF don’t know it. If you and your partner both carry a mutation, your baby could inherit CF. The only way to know your risk is to be tested. You and your doctor can use your test results to learn about your risk and make informed decisions about what’s right for you during your pregnancy.

The test we've developed, the HerediT Cystic Fibrosis Carrier Screen, is the best in class for determining whether you or your partner is a carrier for cystic fibrosis. The test is available for everyone, and may be especially useful if you or your partner has a family history of CF or have other findings that indicate an increased risk for CF, so ask your doctor about the HerediT Cystic Fibrosis Carrier Screen.

 

Simple answers to important questions.

Cystic fibrosis is one of the most common genetic conditions in the United States. Changes in the CFTR gene cause the body to produce thick sticky mucus in the lungs, pancreas and other organs that can affect breathing and digestion. CF does not affect everyone the same way - some people may be more severely affected than others. Symptoms can range from moderate to severe and can even impact fertility. The average lifespan of someone with CF is 37 years33.

It is estimated that more than 10 million Americans are carriers of CF. While the risk of being a CF carrier is dependent upon one's ethnicity and family history, individuals of all racial and ethnic groups may be carriers.

For more information, please visit the Johns Hopkins CFTR2 website.

Cystic fibrosis is inherited in a recessive pattern. This means that in order to be affected a person must inherit two disease-causing mutations - one from each parent. Both parents must be carriers of one of the CF disease-causing mutations in order for them to be at risk of having an affected child. Carriers have only one mutation and usually have no symptoms of CF.

If both parents are carriers, there is a 1 in 4 (25%) chance with each pregnancy that a child will have CF. It is estimated that 1 in 25 Americans are carriers of CF34.

The HerediT Cystic Fibrosis Carrier Screen tests your DNA for the mutations that cause cystic fibrosis. Your health care provider will take the sample (blood or cheek swab) in his or her office and send it to our laboratory. Test results are typically reported to your health care provider approximately 7 days after our laboratory receives your sample. Your result with either be positive (you are a carrier of the CF mutation) or negative (you are not a carrier of the CF mutation).

 

No test is perfect.

While results of the HerediT Cystic Fibrosis Carrier Screen test are highly accurate, a negative result significantly reduces but does not eliminate the chance of being a carrier.  The results of this testing, including the benefits and limitations, should be discussed with your health care provider.

 

To learn more about the HerediT Cystic Fibrosis Carrier Screen test, view and/or download this patient brochure.

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